{"product_id":"kpv","title":"KPV","description":"\u003cp class=\"font-claude-response-body break-words whitespace-normal\" dir=\"ltr\"\u003eKPV is a naturally occurring tripeptide (L-lysine–L-proline–L-valine) corresponding to the C-terminal fragment of alpha-melanocyte-stimulating hormone, α-MSH(11–13). It is the smallest sequence of the parent hormone that retains the hormone's anti-inflammatory activity, while carrying none of its pigmentary effects. Its short chain gives it unusual stability and the ability to cross cell membranes intact.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal\" dir=\"ltr\"\u003e\u003cstrong\u003eMechanism\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal\" dir=\"ltr\"\u003eUnlike most peptides, KPV acts both at the cell surface and inside the cell. Research indicates it is transported into the cytoplasm, where it interferes with pro-inflammatory signalling by suppressing NF-κB nuclear translocation and downstream MAP kinase activity. The result is a reduction in the production of inflammatory cytokines such as TNF-α, IL-6 and IL-1β at their source, rather than a blockade of a single receptor.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal\" dir=\"ltr\"\u003e\u003cstrong\u003eWhat the research shows\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul dir=\"ltr\" class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3 print:block print:space-y-1\"\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eMarked reduction in inflammatory cytokine expression in epithelial and immune cell models\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eImproved intestinal barrier integrity and reduced colonic inflammation in experimental colitis models\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eAccelerated wound closure and reduced tissue oedema in dermal repair studies\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eAntimicrobial activity against several bacterial and fungal strains in vitro\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eStable enough for oral, topical and parenteral administration in research settings — rare among peptides\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal\" dir=\"ltr\"\u003eKPV is studied as a broad, well-tolerated anti-inflammatory signal that works upstream of the inflammatory cascade, which is why it appears across gut, skin and joint research literature.\u003c\/p\u003e","brand":"Space Pep","offers":[{"title":"10 mg","offer_id":49064046002420,"sku":null,"price":6600.0,"currency_code":"EGP","in_stock":true},{"title":"10 mg - Kit (4 vials)","offer_id":49064046035188,"sku":null,"price":23600.0,"currency_code":"EGP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0842\/2644\/1460\/files\/4_e77f39ab-ccf9-4a6f-8f33-184fd062361d.png?v=1785767810","url":"https:\/\/www.spacepep.net\/products\/kpv","provider":"Space Pep","version":"1.0","type":"link"}