{"product_id":"slu-pp-332","title":"SLU-PP-332","description":"\u003cp class=\"font-claude-response-body break-words whitespace-normal\" dir=\"ltr\"\u003eSLU-PP-332 is a synthetic small-molecule pan-agonist of the estrogen-related receptors (ERRα, ERRβ and ERRγ), developed at Saint Louis University. It is not a peptide but a nuclear receptor ligand, and it is studied as a pharmacological \"exercise mimetic\" — a compound that activates the same transcriptional programme skeletal muscle switches on in response to endurance training.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal\" dir=\"ltr\"\u003e\u003cstrong\u003eMechanism\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal\" dir=\"ltr\"\u003eThe estrogen-related receptors are master transcriptional regulators of oxidative metabolism. Working with the coactivator PGC-1α, they govern mitochondrial biogenesis, fatty acid oxidation, and the shift toward slow-twitch, fatigue-resistant muscle fibre characteristics. SLU-PP-332 activates this axis directly, inducing the exercise-responsive gene network without the mechanical stimulus of training itself.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal\" dir=\"ltr\"\u003e\u003cstrong\u003eWhat the research shows\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul dir=\"ltr\" class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3 print:block print:space-y-1\"\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eSignificant increase in running endurance and time-to-exhaustion in rodent performance models\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eUpregulation of mitochondrial biogenesis and oxidative phosphorylation gene programmes in skeletal muscle\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eIncreased whole-body energy expenditure and enhanced fatty acid oxidation\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003eReduction in fat mass and improved metabolic parameters in diet-induced obesity models, without suppression of food intake\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003ePreservation of lean tissue alongside fat loss in metabolic studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal\" dir=\"ltr\"\u003eSLU-PP-332 is of particular interest in research into metabolic capacity, endurance physiology and conditions where exercise is beneficial but not achievable.\u003c\/p\u003e","brand":"Space Pep","offers":[{"title":"10 mg","offer_id":49064008777972,"sku":null,"price":8900.0,"currency_code":"EGP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0842\/2644\/1460\/files\/SLU-PP-332.png?v=1785766565","url":"https:\/\/www.spacepep.net\/products\/slu-pp-332","provider":"Space Pep","version":"1.0","type":"link"}