HGH Fragment 176-191

HGH Fragment 176-191 is a synthetic peptide corresponding to amino acids 176 through 191 at the C-terminus of the human growth hormone molecule — the specific region responsible for growth hormone's fat-metabolising activity. It was developed on the premise that this single functional domain could be isolated from the rest of the hormone. It is closely related to AOD-9604, a modified version of the same region with an extra tyrosine added for stability.

Mechanism

Studies indicate the fragment stimulates lipolysis in adipose tissue and inhibits lipogenesis, reproducing the metabolic effect of intact growth hormone on fat stores. Because the sequence excludes the domains that bind the growth hormone receptor's growth-promoting and glucoregulatory pathways, it does not raise IGF-1, does not stimulate skeletal or soft tissue growth, and has not been shown to affect insulin sensitivity or blood glucose in study conditions. This separation of effects is the entire reason the fragment is of interest.

What the studies show

• Increased lipolytic activity and fat oxidation in adipose tissue models
• Reduced adipogenesis and lipid accumulation in fat cell studies
• No measurable elevation of IGF-1 or growth-promoting activity, unlike full-length growth hormone
• No adverse effect on glucose tolerance or insulin sensitivity in study conditions
• Additional interest in cartilage regeneration and joint tissue repair

The fragment is examined as a targeted metabolic tool: the fat-mobilising action of growth hormone, isolated from its systemic effects.

Frequently asked questions

How much does HGH Fragment 176-191 cost in Egypt?
Prices for the 10-vial and 3-vial options are shown in Egyptian pounds on this page and kept up to date, so there is no need to message for a quote.

Is HGH Fragment 176-191 the same as AOD-9604?
They are close relatives, not the same. HGH Fragment 176-191 is the unmodified end of the growth hormone molecule. AOD-9604 is a modified version with an extra tyrosine added for stability, and it is the form that went through human trials.

Does HGH Fragment 176-191 raise IGF-1?
No. It contains only the fat-metabolising region of growth hormone, so it does not raise IGF-1 or drive growth the way full growth hormone does.

How long does delivery take in Egypt?
Orders typically arrive within 3 to 5 days, delivered to every governorate, in insulated packaging with cold packs.

See also AOD-9604 and Retatrutide, or browse the full fat loss and metabolic range in Egypt.